Abstract
CD147 and ABCG2 both have been reported to mediate Multidrug resistance (MDR) in breast cancer. Recent study demonstrates that CD147 could form a complex with ABCG2 on the cell membrane in primary effusion lymphoma. However, whether these two molecules regulate each other in breast cancer and result in MDR is not clear. We established four MCF-7 cell lines transfected with CD147 and/or ABCG2 and found that CD147 could increase the expression and dimerization of ABCG2, affect its cellular localization and regulate its drug transporter function. The findings derived from cells were confirmed subsequently in clinic samples of chemotherapy-sensitive/resistant breast cancer.
Keywords:
ABCG2; Breast cancer; CD147; Chemoresistance.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / metabolism*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Basigin / genetics
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Basigin / metabolism*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Resistance, Neoplasm*
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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MCF-7 Cells
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Protein Multimerization
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Protein Transport
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RNA / metabolism
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Retrospective Studies
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Time Factors
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Transfection
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Treatment Outcome
Substances
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ABCG2 protein, human
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters
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BSG protein, human
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Neoplasm Proteins
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Basigin
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RNA