Abstract
Cancer is often caused by deregulation of normal developmental processes. Here, we review recent research on the aberrant activation of two hematopoietic cytokine receptors in acute lymphoid leukemias. Somatic events in the genes for thymic stromal lymphopoietin and Interleukin 7 receptors as well as in their downstream JAK kinases result in constitutive ligand-independent activation of survival and proliferation in B and T lymphoid precursors. Drugs targeting these receptors or the signaling pathways might provide effective therapies of these leukemias.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Cytokines / immunology*
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Humans
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Interleukin-7 / immunology*
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Intracellular Signaling Peptides and Proteins
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Janus Kinases / genetics
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Janus Kinases / metabolism
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Models, Biological*
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Mutation / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Precursor Cells, B-Lymphoid / immunology
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Precursor Cells, T-Lymphoid / immunology
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Proteins / genetics
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Proteins / metabolism
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Receptors, Cytokine / genetics
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Receptors, Cytokine / metabolism*
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Receptors, Interleukin-7 / genetics
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Receptors, Interleukin-7 / metabolism*
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Signal Transduction / genetics
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Signal Transduction / immunology*
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Thymic Stromal Lymphopoietin
Substances
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Adaptor Proteins, Signal Transducing
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CRLF2 protein, human
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Cytokines
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Interleukin-7
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Intracellular Signaling Peptides and Proteins
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Proteins
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Receptors, Cytokine
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Receptors, Interleukin-7
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SH2B3 protein, human
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Janus Kinases
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Thymic Stromal Lymphopoietin