Abstract
The adenovirus E1A C-terminal region restrains oncogenic transformation through interaction with three distinct cellular protein complexes that include the DYRK1A/1B/HAN11 complex. The E6 proteins of beta-human papillomaviruses (beta-HPVs) also interact with the DYRK1/HAN11 complex. A variant of HPV5 E6 frequently found in epidermodysplasia verruciformis skin lesions interacted less efficiently with DYRK1A/HAN11. The E6 variant and E7 of HPV5 efficiently coimmortalized primary epithelial cells, suggesting that naturally arising variants may contribute potential oncogenic activities of beta-HPV E6 proteins.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Adenovirus E1A Proteins / genetics
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Adenovirus E1A Proteins / metabolism*
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Amino Acid Sequence
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Betapapillomavirus / metabolism*
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Blotting, Western
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Cell Transformation, Neoplastic / metabolism*
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Dyrk Kinases
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Humans
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Immunoprecipitation
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Molecular Sequence Data
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Multiprotein Complexes / genetics
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Multiprotein Complexes / metabolism*
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / metabolism*
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism
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Sequence Homology
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Virus Replication / genetics
Substances
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Adaptor Proteins, Signal Transducing
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Adenovirus E1A Proteins
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DCAF7 protein, human
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E6 protein, human papillomavirus type 5
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Multiprotein Complexes
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Oncogene Proteins, Viral
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Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases