The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Marco Locatelli; Stefano Ferrero; Filippo Martinelli Boneschi; Leonardo Boiocchi; Mario Zavanone; Sergio Maria Gaini; Lorenzo Bello; Sonia Valentino; Elisa Barbati; Manuela Nebuloni; Alberto Mantovani; Cecilia Garlanda

doi:10.1016/j.jneuroim.2013.04.009

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

J Neuroimmunol. 2013 Jul 15;260(1-2):99-106. doi: 10.1016/j.jneuroim.2013.04.009. Epub 2013 May 9.

Authors

Marco Locatelli¹, Stefano Ferrero, Filippo Martinelli Boneschi, Leonardo Boiocchi, Mario Zavanone, Sergio Maria Gaini, Lorenzo Bello, Sonia Valentino, Elisa Barbati, Manuela Nebuloni, Alberto Mantovani, Cecilia Garlanda

Affiliation

¹ Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.

PMID: 23664694
DOI: 10.1016/j.jneuroim.2013.04.009

Abstract

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, CD / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Brain Neoplasms / immunology*
Brain Neoplasms / metabolism
Brain Neoplasms / pathology
C-Reactive Protein / genetics
C-Reactive Protein / immunology*
C-Reactive Protein / metabolism
DNA Modification Methylases / genetics
DNA Repair Enzymes / genetics
Encephalitis / immunology*
Encephalitis / metabolism
Encephalitis / pathology
Female
Glioblastoma / immunology*
Glioblastoma / metabolism
Glioblastoma / pathology
Humans
Logistic Models
Macrophages / immunology
Male
Middle Aged
Multivariate Analysis
Neoplasm Grading
Oligodendroglioma / immunology*
Oligodendroglioma / metabolism
Oligodendroglioma / pathology
Predictive Value of Tests
Prognosis
Serum Amyloid P-Component / genetics
Serum Amyloid P-Component / immunology*
Serum Amyloid P-Component / metabolism
Severity of Illness Index
Tumor Suppressor Proteins / genetics

Substances

Antigens, CD
Antigens, Differentiation, Myelomonocytic
Biomarkers, Tumor
CD68 antigen, human
Serum Amyloid P-Component
Tumor Suppressor Proteins
PTX3 protein
C-Reactive Protein
DNA Modification Methylases
MGMT protein, human
DNA Repair Enzymes