Mutation analysis of papillary tubal hyperplasia associated with ovarian atypical proliferative serous tumor and low-grade serous carcinoma

Wen-Chih Huang; Chien-Chen Tsai; Ming-Chow Wei; Kuan-Ting Kuo

doi:10.1016/j.ajog.2013.05.044

Mutation analysis of papillary tubal hyperplasia associated with ovarian atypical proliferative serous tumor and low-grade serous carcinoma

Am J Obstet Gynecol. 2013 Aug;209(2):e6-8. doi: 10.1016/j.ajog.2013.05.044. Epub 2013 May 24.

Authors

Wen-Chih Huang¹, Chien-Chen Tsai, Ming-Chow Wei, Kuan-Ting Kuo

Affiliation

¹ Department of Anatomic Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan.

PMID: 23711666
DOI: 10.1016/j.ajog.2013.05.044

Abstract

We present a patient with ovarian atypical proliferative serous tumor and low-grade serous carcinoma, related to KRAS mutation. Bilateral fallopian tubes had papillary tubal hyperplasia, providing additional evidence that it is the putative precursor of low-grade serous tumors. Mutation analysis of papillary tubal hyperplasia has not been done in previous literature.

Keywords: KRAS mutation; low-grade serous carcinoma; ovary atypical proliferative serous tumor; papillary tubal hyperplasia; serous borderline tumor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cystadenocarcinoma, Serous / genetics*
DNA Mutational Analysis
Fallopian Tube Neoplasms / genetics*
Fallopian Tube Neoplasms / pathology
Fallopian Tubes / pathology*
Female
Humans
Hyperplasia
Middle Aged
Mutation*
Neoplasm Staging
Ovarian Neoplasms / genetics*
Precancerous Conditions / genetics*
Precancerous Conditions / pathology
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins p21(ras)
ras Proteins / genetics*

Substances

KRAS protein, human
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins