A case of lung adenocarcinoma harboring exon 19 EGFR deletion and EML4-ALK fusion gene

Xiaoxia Chen; Jie Zhang; Qiong Hu; Xuefei Li; Caicun Zhou

doi:10.1016/j.lungcan.2013.05.003

A case of lung adenocarcinoma harboring exon 19 EGFR deletion and EML4-ALK fusion gene

Lung Cancer. 2013 Aug;81(2):308-10. doi: 10.1016/j.lungcan.2013.05.003. Epub 2013 May 31.

Authors

Xiaoxia Chen¹, Jie Zhang, Qiong Hu, Xuefei Li, Caicun Zhou

Affiliation

¹ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Tongji University Medical School Cancer Institute Tongji University, No 507 Zhengmin Road, Shanghai 200433, People's Republic of China.

PMID: 23731739
DOI: 10.1016/j.lungcan.2013.05.003

Abstract

We report a man with advanced adenocarcinoma who harboring exon 19 (E746-A750del) epidermal growth factor receptor (EGFR) deletion and echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation in the re-biospy specimen. The patient was treated with erlotinib with a stable disease but progressed slowly, while crizotinib showed a complete response.

Keywords: Acquired resistance; Adenocarcinoma; EGFR mutation; EML4-ALK fusion; Lung.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / genetics*
Adenocarcinoma of Lung
ErbB Receptors / genetics*
Exons*
Gene Deletion
Humans
Lung Neoplasms / genetics*
Male
Middle Aged
Oncogene Proteins, Fusion / genetics*

Substances

EML4-ALK fusion protein, human
Oncogene Proteins, Fusion
EGFR protein, human
ErbB Receptors