The B cell antigen CD75 is a cell surface sialytransferase

I Stamenkovic; H C Asheim; A Deggerdal; H K Blomhoff; E B Smeland; S Funderud

doi:10.1084/jem.172.2.641

The B cell antigen CD75 is a cell surface sialytransferase

J Exp Med. 1990 Aug 1;172(2):641-3. doi: 10.1084/jem.172.2.641.

Authors

I Stamenkovic¹, H C Asheim, A Deggerdal, H K Blomhoff, E B Smeland, S Funderud

Affiliation

¹ Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.

Abstract

In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialytransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.

MeSH terms

Amino Acid Sequence
Animals
B-Lymphocytes / enzymology
B-Lymphocytes / immunology*
Base Sequence
Burkitt Lymphoma
Cell Line
DNA, Neoplasm / genetics
DNA, Neoplasm / isolation & purification
Gene Library
Glycosylation
Humans
Molecular Sequence Data
RNA, Neoplasm / genetics
RNA, Neoplasm / isolation & purification
Sialyltransferases / genetics*
Transfection

Substances

DNA, Neoplasm
RNA, Neoplasm
Sialyltransferases