Abstract
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder that occurs because of t(9;22)(q34;q11) translocations. Complex translocations have been reported in CML. We report a novel 5-way translocation 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21) using GTG banding, fluorescence in situ hybridization, and spectral karyotyping in a case of chronic-phase CML. Molecular analysis revealed the presence of 2 types of transcripts (b3a2, b2a2). The patient was responding to the imatinib treatment. However, the patient needs to be carefully monitored at various intervals.
Keywords:
5-Way translocation; BCR/ABL gene; Chronic myeloid leukemia; Chronic phase.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Antineoplastic Agents / therapeutic use
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Benzamides / therapeutic use
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Chromosomes, Human, Pair 11* / genetics
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Chromosomes, Human, Pair 13* / genetics
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Chromosomes, Human, Pair 19* / genetics
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Chromosomes, Human, Pair 22* / genetics
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Chromosomes, Human, Pair 9* / genetics
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Humans
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Imatinib Mesylate
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In Situ Hybridization, Fluorescence
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
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Male
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Piperazines / therapeutic use
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Pyrimidines / therapeutic use
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Spectral Karyotyping
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Translocation, Genetic / genetics*
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Treatment Outcome
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Pyrimidines
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Imatinib Mesylate