RAP1: protector of telomeres, defender against obesity

MyLinh T Duong; Ergün Sahin

doi:10.1016/j.celrep.2013.06.011

RAP1: protector of telomeres, defender against obesity

Cell Rep. 2013 Jun 27;3(6):1757-8. doi: 10.1016/j.celrep.2013.06.011.

Authors

MyLinh T Duong¹, Ergün Sahin

Affiliation

¹ Huffington Center on Aging and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

PMID: 23809762
DOI: 10.1016/j.celrep.2013.06.011

Abstract

Telomere dysfunction has previously been linked to metabolic disorders. In this issue of Cell Reports, Martínez et al. (2013) and Yeung et al. (2013) now extend this link, demonstrating that deletion of the telomere binding protein RAP1 leads to obesity and insulin resistance.

Publication types

Comment

MeSH terms

Animals
Body Weight / genetics*
Female
Humans
Male
Obesity / genetics*
Telomere / metabolism*
Telomere-Binding Proteins / genetics*
rap1 GTP-Binding Proteins / metabolism*

Substances

Telomere-Binding Proteins
rap1 GTP-Binding Proteins