Scanning for clues to better use selective estrogen receptor modulators

Cancer Discov. 2013 Jul;3(7):728-9. doi: 10.1158/2159-8290.CD-13-0251.

Abstract

Ingle and colleagues present timely findings identifying genetic variants associated with response to selective estrogen receptor modulator therapy that when substantiated in follow-up may represent an important step toward understanding estrogen-dependent induction of BRCA1 expression and advancing individualized preventive medicine in women at high risk for developing breast cancer.

MeSH terms

  • BRCA1 Protein / genetics
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Estrogens / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic / drug effects
  • Genome-Wide Association Study
  • Humans
  • Neoplasms, Hormone-Dependent / genetics*
  • Neoplasms, Hormone-Dependent / pathology
  • Neoplasms, Hormone-Dependent / therapy
  • Receptors, Estrogen / metabolism*
  • Selective Estrogen Receptor Modulators / administration & dosage*
  • Selective Estrogen Receptor Modulators / adverse effects

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • Estrogens
  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators