Abstract
Somatic ERBB3 hot-spot mutations promote oncogenic signaling in a subset of human tumors.
MeSH terms
-
Animals
-
Breast Neoplasms / genetics*
-
Breast Neoplasms / pathology
-
Carcinogenesis*
-
Cell Line, Tumor
-
Female
-
Gene Expression Regulation, Neoplastic
-
Humans
-
Mice
-
Mutation
-
Receptor, ErbB-2 / genetics
-
Receptor, ErbB-2 / metabolism
-
Receptor, ErbB-3 / genetics
-
Receptor, ErbB-3 / metabolism*
-
Signal Transduction / genetics
-
Xenograft Model Antitumor Assays
Substances
-
ERBB2 protein, human
-
ERBB3 protein, human
-
Receptor, ErbB-2
-
Receptor, ErbB-3