Background: The potentially functionally relevant IL10 -1082A>G (rs1800896) promoter region single-nucleotide polymorphism has been implicated in the pathogenesis of atopic dermatitis (AD). Although this relationship has been studied extensively, these association studies were limited by small sample size.
Objective: To increase statistical power and obtain a more precise estimate of the association, literature evidence on IL10 -1082A>G and AD was assessed by conducting a systematic review and meta-analysis.
Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder literature databases were systematically searched for relevant studies. Summary odds ratios and corresponding 95% confidence intervals were estimated using the fixed-effect inverse variance analysis method for allelic (G vs A) and genotypic comparisons.
Results: Meta-analysis of 7 studies (n = 849 cases and 1195 controls) found a nonsignificant association between the IL10 -1082A>G polymorphism and AD (allelic odds ratio, 1.02; 95% confidence interval, 0.88-1.19; P = 0.77).
Conclusions: This study was unable to find a direct association between IL10 -1082A>G and AD. Further studies are needed to reveal the contributions of haplotype and gene-gene and gene-environment interaction effects involving this single-nucleotide polymorphism to AD.