Abstract
Recent studies have identified recurrent mutations in SETBP1, the gene that encodes SET-binding protein 1, in several types of myeloid malignancies, including chronic myeloid and acute myeloid leukemias. The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.
Publication types
-
News
-
Research Support, Non-U.S. Gov't
-
Comment
MeSH terms
-
Animals
-
Carrier Proteins / genetics*
-
Exome*
-
Female
-
Humans
-
Janus Kinase 3 / genetics*
-
Leukemia, Myeloid / genetics*
-
Leukemia, Myelomonocytic, Juvenile / genetics*
-
Male
-
Mutation*
-
Myeloproliferative Disorders / genetics*
-
Nuclear Proteins / genetics*
Substances
-
Carrier Proteins
-
Nuclear Proteins
-
SETBP1 protein, human
-
Janus Kinase 3