Nek8 couples renal ciliopathies to DNA damage and checkpoint control

Mol Cell. 2013 Aug 22;51(4):407-8. doi: 10.1016/j.molcel.2013.08.013.

Abstract

In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.

Publication types

  • Comment

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism*
  • Cilia / pathology*
  • Cyclin-Dependent Kinases / metabolism*
  • DNA Replication / genetics*
  • Humans
  • NIMA-Related Kinases
  • Polycystic Kidney Diseases / pathology*
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • S Phase / physiology*

Substances

  • Cell Cycle Proteins
  • Protein Kinases
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • NEK8 protein, human
  • NIMA-Related Kinases
  • Protein Serine-Threonine Kinases
  • Cyclin-Dependent Kinases