Abstract
In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Ataxia Telangiectasia Mutated Proteins
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Cell Cycle Proteins / metabolism*
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Cilia / pathology*
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Cyclin-Dependent Kinases / metabolism*
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DNA Replication / genetics*
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Humans
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NIMA-Related Kinases
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Polycystic Kidney Diseases / pathology*
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases / metabolism*
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S Phase / physiology*
Substances
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Cell Cycle Proteins
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Protein Kinases
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ATR protein, human
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Ataxia Telangiectasia Mutated Proteins
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NEK8 protein, human
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NIMA-Related Kinases
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Protein Serine-Threonine Kinases
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Cyclin-Dependent Kinases