Abstract
Forkhead box M1 (FoxM1) is a member of the forkhead transcription factor family and is overexpression in malignant gliomas. However, the molecular mechanisms by which FoxM1lead to glioma carcinogenesis and progression are still not well known. In the present study, we show that Anxa1 was overexpression in gliomas and predicted the poor outcome. Furthermore, Anxa1 closely related to the FoxM1 expression and was a direct transcriptional target of FoxM1. Overexpression of FoxM1 up-regulated Anxa1 expression, whereas suppression of FoxM1 expression down-regulated Anxa1 expression in glioma cells. Finally, FoxM1 enhanced the proliferation, migration, and angiogenesis in Anxa1-dependent manner both in vitro and in vivo. Our findings provide both clinical and mechanistic evidences that FoxM1 contributes to glioma development by directly up-regulating Anxa1 expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Annexin A1 / genetics
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Annexin A1 / metabolism*
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Base Sequence
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Blotting, Western
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Chromatin Immunoprecipitation
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DNA Primers
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Disease Progression
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Forkhead Box Protein M1
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Forkhead Transcription Factors / physiology*
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Glioblastoma / metabolism
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Glioblastoma / pathology*
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Humans
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Prognosis
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Promoter Regions, Genetic
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
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Tumor Cells, Cultured
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Up-Regulation*
Substances
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Annexin A1
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DNA Primers
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FOXM1 protein, human
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Forkhead Box Protein M1
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Forkhead Transcription Factors
Grants and funding
This work was supported by the National Natural Science Foundation of China (31200809) and intramural research programs from Logistics College of CPAPF (FYZ201201 and WYM201109). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.