Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder

Ali Sazci; Mavi Deniz Ozel; Emel Ergul; Mehmet Emin Onder

doi:10.1016/j.gene.2013.08.077

Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder

Gene. 2013 Dec 15;532(2):272-5. doi: 10.1016/j.gene.2013.08.077. Epub 2013 Sep 1.

Authors

Ali Sazci¹, Mavi Deniz Ozel, Emel Ergul, Mehmet Emin Onder

Affiliation

¹ Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380 Kocaeli, Turkey. Electronic address: alisazci@gmail.com.

PMID: 24004542
DOI: 10.1016/j.gene.2013.08.077

Abstract

Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (χ(2)=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease.

Keywords: Association; Bipolar disorder; CI; Gender; HWE; Hardy–Weinberg equilibrium; MTHFR; NNMT; NNMT gene; OR; PAGE; PCR; PCR-RFLP; Turkey; confidence interval; methylenetetrahyrofolate reductase; nicotinamide-N-methyltransferase; odds ratio; polyacrylamide gel electrophoresis; polymerase chain reaction; polymerase chain reaction-restriction fragment length polymorphism; rs694539.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bipolar Disorder / enzymology
Bipolar Disorder / genetics*
Case-Control Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Nicotinamide N-Methyltransferase / genetics*
Odds Ratio
Polymorphism, Single Nucleotide*
Sequence Analysis, DNA
Young Adult

Substances

NNMT protein, human
Nicotinamide N-Methyltransferase