Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder

J Affect Disord. 2013 Nov;151(2):744-747. doi: 10.1016/j.jad.2013.08.012. Epub 2013 Aug 23.

Abstract

The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes-CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We examined 560 patients with diagnosis of bipolar disorder (n=457) and unipolar disorder (n=103). Diagnosis was established by SCID and OPCRIT. We found association between polymorphisms of AVPR1b gene and psychotic dimension and CRHR1 polymorphisms and excitement and psychotic dimension. Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder.

Keywords: Bipolar disorder; Genes; HPA axis; OPCRIT dimension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bipolar Disorder / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Receptors, Corticotropin-Releasing Hormone / genetics*
  • Receptors, Glucocorticoid / genetics*
  • Receptors, Vasopressin / genetics

Substances

  • NR3C1 protein, human
  • Receptors, Corticotropin-Releasing Hormone
  • Receptors, Glucocorticoid
  • Receptors, Vasopressin