Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population

Xian-cang Ma; Ce Chen; Feng Zhu; Wei Jia; Cheng-ge Gao

doi:10.1016/j.psychres.2013.08.025

Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population

Psychiatry Res. 2013 Dec 30;210(3):1296-8. doi: 10.1016/j.psychres.2013.08.025. Epub 2013 Sep 7.

Authors

Xian-cang Ma¹, Ce Chen, Feng Zhu, Wei Jia, Cheng-ge Gao

Affiliation

¹ Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.

PMID: 24022000
DOI: 10.1016/j.psychres.2013.08.025

Abstract

The association of seven GDNF tag SNPs with depression, heroin dependence (HD) and schizophrenia was evaluated in Chinese. An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.

Keywords: Depression; Glial cell line-derived neurotrophic factor; Heroin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Asian People / genetics*
Asian People / psychology
Case-Control Studies
Depression / ethnology
Depression / genetics*
Depression / psychology
Depressive Disorder / genetics
Genetic Predisposition to Disease / ethnology
Genetic Predisposition to Disease / genetics*
Genotype
Glial Cell Line-Derived Neurotrophic Factor / genetics*
Heroin Dependence / ethnology
Heroin Dependence / genetics*
Heroin Dependence / psychology
Humans
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Schizophrenia / genetics
Schizophrenic Psychology

Substances

Glial Cell Line-Derived Neurotrophic Factor