Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease

Xuting Xu; Yunliang Wang; Lingyan Wang; Qi Liao; Lan Chang; Leiting Xu; Yi Huang; Huadan Ye; Limin Xu; Cheng Chen; Xiaowei Shen; Fuqiang Zhang; Meng Ye; Qinwen Wang; Shiwei Duan

doi:10.1371/journal.pone.0073129

Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease

PLoS One. 2013 Sep 10;8(9):e73129. doi: 10.1371/journal.pone.0073129. eCollection 2013.

Authors

Xuting Xu¹, Yunliang Wang, Lingyan Wang, Qi Liao, Lan Chang, Leiting Xu, Yi Huang, Huadan Ye, Limin Xu, Cheng Chen, Xiaowei Shen, Fuqiang Zhang, Meng Ye, Qinwen Wang, Shiwei Duan

Affiliation

¹ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.

Abstract

Aims: The aim of this study was to evaluate the combined contribution of 8 polymorphisms to the risk of Alzheimer's disease (AD).

Methods: Through a comprehensive literature search for genetic variants involved in the AD association study, we harvested a total of 6 genes (8 polymorphisms) for the current meta-analyses. These genes consisted of A2M (5bp I/D and V1000I), ABCA2 (rs908832), CHAT (1882G >A, 2384G >A), COMT (Val158Met), HTR6 (267C >T) and LPL (Ser447Ter).

Results: A total of 33 studies among 9,453 cases and 10,833 controls were retrieved for the meta-analyses of 8 genetic variants. It was showed that A2M V1000I (odd ratio (OR) = 1.26, 95% confidence interval (CI) = 1.07-1.49, P = 0.007), rs908832 allele of ABCA2 (OR = 1.55, 95% CI = 1.12-2.16, P = 0.009), 2384G >A of CHAT (OR = 1.22, 95% CI = 1.00-1.49, P = 0.05) and Ser447Ter of LPL in the Northern-American population (OR = 0.56, 95% CI = 0.35-0.91, P = 0.02) were significantly associated with the risk of AD. No association was found between the rest of the 5 polymorphisms and the risk of AD.

Conclusion: Our results showed that A2M V1000I polymorphism in German, Korean, Chinese, Spanish, Italian and Polish populations, rs90883 of ABCA2 gene in French, American, Swiss, Greek and Japanese populations, 2384G >A of CHAT gene in British and Korean populations and LPL Ser447Ter in the Northern-American population were associated with the risk of AD.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Alzheimer Disease / genetics*
Amino Acid Substitution
Genetic Predisposition to Disease*
Genotype
Humans
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Risk

Grants and funding

The research was supported by the grants from the National Natural Science Foundation of China (31100919, 81070873, and 81271209), Natural Science Foundation of Zhejiang Province (LR13H020003), K. C. Wong Magna Fund in Ningbo University, Ningbo social development research projects (2012C50032), Science and Technology Innovation team of Ningbo (2011B82014), the neurobiological mechanisms of drug-reward: role of the habenula National Natural Science Foundation of China (81171257), and Research Fund in Ningbo University (XKL11D2117). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.