Abstract
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cell Nucleus / metabolism
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Cell Nucleus / virology
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Cytoplasm / metabolism
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Cytoplasm / virology*
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Down-Regulation
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Genome, Viral*
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Host-Pathogen Interactions
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Humans
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Influenza A Virus, H3N2 Subtype / genetics*
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Influenza A Virus, H3N2 Subtype / physiology
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Influenza, Human / genetics
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Influenza, Human / metabolism*
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Influenza, Human / virology*
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Interferon-alpha / metabolism*
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Myxovirus Resistance Proteins / genetics
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Myxovirus Resistance Proteins / metabolism*
Substances
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Interferon-alpha
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MX1 protein, human
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Myxovirus Resistance Proteins