The aim of this study was to investigate the association between C-reactive protein (CRP) gene polymorphism and metabolic syndrome (MetS) with premature coronary artery disease (PCAD). 116 patients with PCAD (58 with MetS and 58 without MetS) and 119 controls were included in the study. CRP gene +1059 G>C polymorphism was analyzed by polymerase chain reaction. Serum hs-CRP was measured using high-sensitivity enzyme-linked immunosorbent assay. Carriers of C allele of the CRP +1059 G>C polymorphism had 3.37 fold increased risk to develop MetS in patients with PCAD. In addition CRP gene and hs-CRP levels were independent risk factors for PCAD and MetS. The present study provides new evidence that the presence of CRP +1059 G>C polymorphism and hs-CRP levels are independent determinants of PCAD and MetS in Egyptians. The results of our study suggest a synergistic effect of CRP C allele with classical risk factors such as hypertension, obesity, dyslipidemia and MetS.
Keywords: C-reactive protein; CAD; CRP; CRP gene; Coronary artery disease; ELISA; HDLc; High-density lipoprotein cholesterol; High-sensitivity C-reactive protein; High-sensitivity enzyme-linked immunosorbent assay; LDLc; Low density lipoprotein cholesterol; MetS; Metabolic syndrome; PCAD; Polymorphism; Premature CAD; Premature coronary artery disease; SNPs; Single nucleotide polymorphisms; TC; TG; TNF-α; Total cholesterol; Triglycerides; Tumor necrotizing factor-α; hs-CRP.
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