Abstract
The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls. The eGFRs were significantly lower in the HF subjects with the ALDH2 *2/*2 genotype than in those with the other genotypes. Multiple regression analyses adjusted by the potentially confounding factors showed the *2/*2 genotype to be significantly associated with the decreased eGFR, compared to the *1/*1 genotype (β = 31.99 ml min1 per 1.73 m2, P < 0.01).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aldehyde Dehydrogenase / genetics
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Aldehyde Dehydrogenase / physiology*
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Aldehyde Dehydrogenase, Mitochondrial
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Alleles
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Asian People / genetics
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Case-Control Studies
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Coronary Artery Disease / complications
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Cross-Sectional Studies
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Female
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Genetic Predisposition to Disease / genetics
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Genotype
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Glomerular Filtration Rate / genetics
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Glomerular Filtration Rate / physiology*
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Heart Failure / complications*
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Humans
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Hypertension / complications*
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Male
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Middle Aged
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Pilot Projects
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Regression Analysis
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Renal Insufficiency / etiology
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Renal Insufficiency / physiopathology*
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Renal Insufficiency / prevention & control*
Substances
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ALDH2 protein, human
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Aldehyde Dehydrogenase
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Aldehyde Dehydrogenase, Mitochondrial