Abstract
Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Child
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Female
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HIV Infections / drug therapy*
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HIV Infections / genetics*
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HIV Infections / urine
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Humans
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Kidney Diseases / chemically induced*
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Kidney Diseases / genetics*
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Kidney Diseases / urine
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Kidney Diseases / virology
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Kidney Tubules / drug effects
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Kidney Tubules / physiopathology
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Male
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins / genetics*
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Organophosphonates / adverse effects*
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Organophosphonates / therapeutic use
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Polymorphism, Single Nucleotide
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Tenofovir
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Young Adult
Substances
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ABCC2 protein, human
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Anti-HIV Agents
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins
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Organophosphonates
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Tenofovir
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Adenine