Abstract
Diabetic nephropathy is the leading cause of chronic kidney disease and end-stage renal disease. Oxidative stress has been recognized as a major contributor to its pathogenesis. Defensive mechanisms have also widely been studied. One of them, the NF-E2-Related Factor 2, is reviewed in this article.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Angiotensin-Converting Enzyme Inhibitors / pharmacology
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Animals
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Anticarcinogenic Agents / pharmacology
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Cytoskeletal Proteins / metabolism
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Diabetic Nephropathies / genetics*
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Isothiocyanates / pharmacology
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Kelch-Like ECH-Associated Protein 1
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Mice
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NF-E2-Related Factor 2 / drug effects
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NF-E2-Related Factor 2 / metabolism*
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Sulfoxides
Substances
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Adaptor Proteins, Signal Transducing
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Angiotensin-Converting Enzyme Inhibitors
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Anticarcinogenic Agents
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Cytoskeletal Proteins
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Intracellular Signaling Peptides and Proteins
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Isothiocyanates
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KEAP1 protein, human
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Keap1 protein, mouse
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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Sulfoxides
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sulforaphane