Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer

Steffi Oesterreich; Adam M Brufsky; Nancy E Davidson

doi:10.1016/j.celrep.2013.09.008

Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer

Cell Rep. 2013 Sep 26;4(6):1061-2. doi: 10.1016/j.celrep.2013.09.008.

Authors

Steffi Oesterreich¹, Adam M Brufsky, Nancy E Davidson

Affiliation

¹ Women's Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Magee-Womens Hospital and Magee-Womens Research Institute, Departments of Pharmacology and Chemical Biology and Medicine, University of Pittsburgh, Pittsburgh 15213, USA. Electronic address: oesterreichs@upmc.edu.

PMID: 24075202
DOI: 10.1016/j.celrep.2013.09.008

Abstract

In this issue of Cell Reports, Li et al. show that the analysis of genetic changes in patient-derived xenografts can reveal crucial details of tumor evolution, such as the emergence of functional estrogen receptor mutations in endocrine-resistant breast cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics*
Estrogen Receptor alpha / genetics*
Female
Humans

Substances

ESR1 protein, human
Estrogen Receptor alpha

Abstract

Publication types

MeSH terms

Substances

Grants and funding