Abstract
Specific antibodies against basement membrane associated, connective tissue components: type IV and V collagens, laminin, fibronectin and heparan sulphate proteoglycan were used to study the basement membrane-like structures in cylindroma lesions. All these components were immunohistochemically demonstrated as a band surrounding islands of epithelial cells and all except fibronectin also inside the islands. Antibodies to keratin filaments stained most of the cells inside the epithelial islands confirming the epithelial origin of the cells.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Basement Membrane / analysis*
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Carcinoma, Adenoid Cystic / analysis
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Carcinoma, Adenoid Cystic / genetics*
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Chondroitin Sulfate Proteoglycans / analysis
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Collagen / analysis
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Female
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Fibronectins / analysis
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Fluorescent Antibody Technique
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Genes, Dominant
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Heparan Sulfate Proteoglycans
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Heparitin Sulfate / analysis
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Humans
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Keratins / analysis*
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Laminin / analysis
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Middle Aged
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Skin Neoplasms / analysis
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Skin Neoplasms / genetics*
Substances
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Chondroitin Sulfate Proteoglycans
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Fibronectins
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Heparan Sulfate Proteoglycans
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Laminin
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Keratins
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Collagen
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Heparitin Sulfate