Neutrality of miniSTR D22S1045 marker by Ewing's sarcoma phenotype

Deborah S B S Silva; Paulo E Raimann; Tatiane Moro; Juliane B Picanço; Ana L Abujamra; Caroline B de Farias; Rafael Roesler; Algemir L Brunetto; Clarice S Alho

doi:10.1016/j.legalmed.2013.08.004

Neutrality of miniSTR D22S1045 marker by Ewing's sarcoma phenotype

Leg Med (Tokyo). 2013 Nov;15(6):335-7. doi: 10.1016/j.legalmed.2013.08.004. Epub 2013 Sep 10.

Authors

Deborah S B S Silva¹, Paulo E Raimann, Tatiane Moro, Juliane B Picanço, Ana L Abujamra, Caroline B de Farias, Rafael Roesler, Algemir L Brunetto, Clarice S Alho

Affiliation

¹ Laboratory of Molecular and Human Genetics, Faculty of Biosciences, PUCRS, 90619-900 Porto Alegre, RS, Brazil.

PMID: 24112992
DOI: 10.1016/j.legalmed.2013.08.004

Abstract

Neutrality investigations of markers with forensic use are important to see if a phenotypic trait is being expressed in relation to the alleles of the marker. MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the EWS gene (22q12.2), which leads to the development of Ewing's Sarcoma. Analyzing allele frequencies and linkage disequilibrium in Ewing's sarcoma patients and non-affected populations, we found that the marker mD22S1045 was neutral when related to Ewing's Sarcoma.

Keywords: Chromosome 22; Ewing’s sarcoma; Forensic markers; MiniSTR; mD22S1045.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
Chromosomes, Human, 21-22 and Y / genetics*
DNA Fingerprinting / methods
Forensic Genetics / methods*
Genetic Markers
Humans
Linkage Disequilibrium / genetics*
Microsatellite Repeats / genetics
Phenotype
Sarcoma, Ewing / genetics*

Substances

Genetic Markers