Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice

Mucosal Immunol. 2014 May;7(3):589-601. doi: 10.1038/mi.2013.78. Epub 2013 Oct 16.

Abstract

The increasing incidence of inflammatory bowel diseases (IBDs) in developing countries has highlighted the critical role of environmental pollutants as causative factors in their pathophysiology. Despite its ubiquity and immune toxicity, the impact of aluminum in the gut is not known. This study aimed to evaluate the effects of environmentally relevant intoxication with aluminum in murine models of colitis and to explore the underlying mechanisms. Oral administration of aluminum worsened intestinal inflammation in mice with 2,4,6-trinitrobenzene sulfonic acid- and dextran sodium sulfate-induced colitis and chronic colitis in interleukin 10-negative (IL10(-/-)) mice. Aluminum increased the intensity and duration of macroscopic and histologic inflammation, colonic myeloperoxidase activity, inflammatory cytokines expression, and decreased the epithelial cell renewal compared with control animals. Under basal conditions, aluminum impaired intestinal barrier function. In vitro, aluminum induced granuloma formation and synergized with lipopolysaccharide to stimulate inflammatory cytokines expression by epithelial cells. Deleterious effects of aluminum on intestinal inflammation and mucosal repair strongly suggest that aluminum might be an environmental IBD risk factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum / adverse effects
  • Aluminum / pharmacology*
  • Aluminum Compounds / pharmacology
  • Animals
  • Cell Line
  • Chronic Disease
  • Colitis / chemically induced
  • Colitis / genetics
  • Colitis / immunology*
  • Colitis / pathology*
  • Cytokines / genetics
  • Cytokines / metabolism
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects
  • Granuloma
  • Humans
  • Inflammation Mediators / metabolism
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / pathology
  • Interleukin-10 / deficiency
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / microbiology
  • Intestinal Mucosa / pathology*
  • Male
  • Mice
  • Mice, Knockout
  • Phosphates / pharmacology
  • Trinitrobenzenesulfonic Acid / adverse effects
  • Wound Healing / drug effects*

Substances

  • Aluminum Compounds
  • Cytokines
  • Inflammation Mediators
  • Phosphates
  • Interleukin-10
  • Trinitrobenzenesulfonic Acid
  • Aluminum
  • aluminum phosphate