Abstract
We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / therapy*
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Cell Line, Tumor
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Drug Carriers / chemistry
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Esophageal Neoplasms / genetics
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Esophageal Neoplasms / pathology
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Esophageal Neoplasms / therapy*
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Gene Expression Regulation, Neoplastic
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Gene Transfer Techniques
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Genetic Therapy / methods*
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Humans
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MicroRNAs / genetics*
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Nanodiamonds / chemistry*
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Nanodiamonds / therapeutic use
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use*
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Protamines / chemistry*
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Protamines / therapeutic use
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RNA, Small Interfering / administration & dosage
Substances
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Drug Carriers
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MIRN203 microRNA, human
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MicroRNAs
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Nanodiamonds
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Protamines
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RNA, Small Interfering