Linking the SWI/SNF complex to prostate cancer

Ryan S Lee; Charles W M Roberts

doi:10.1038/ng.2805

Linking the SWI/SNF complex to prostate cancer

Nat Genet. 2013 Nov;45(11):1268-9. doi: 10.1038/ng.2805.

Authors

Ryan S Lee¹, Charles W M Roberts

Affiliation

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, the Division of Hematology-Oncology, Boston Children's Hospital and the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

PMID: 24165726
DOI: 10.1038/ng.2805

Abstract

Genes encoding subunits of the SWI/SNF chromatin-remodeling complex constitute, collectively, one of the most frequently mutated targets in cancer. Although mutations in SWI/SNF genes are uncommon in prostate cancer, a new study shows that SChLAP1, a long noncoding RNA frequently expressed in aggressive prostate tumors, drives cancer by directly disrupting SNF5, a core subunit of the SWI/SNF complex.

Publication types

Comment

MeSH terms

Animals
Chromosomal Proteins, Non-Histone / genetics*
Chromosomal Proteins, Non-Histone / metabolism*
DNA-Binding Proteins / genetics*
Female
Humans
Male
Prostatic Neoplasms / genetics*
RNA, Long Noncoding / genetics*
SMARCB1 Protein
Transcription Factors / genetics*
Transcription Factors / metabolism*

Substances

Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
RNA, Long Noncoding
SMARCB1 Protein
SMARCB1 protein, human
SWI-SNF-B chromatin-remodeling complex
Transcription Factors