Abstract
Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer's disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / ethnology
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Alzheimer Disease / genetics*
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Apolipoproteins E / genetics*
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Asian People / ethnology
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Asian People / genetics
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Female
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Gene Frequency
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Genetic Association Studies
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Genetic Predisposition to Disease / genetics*
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Genotype
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Humans
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Male
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Membrane Proteins / genetics*
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Nerve Tissue Proteins / genetics*
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Polymorphism, Single Nucleotide / genetics*
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Risk
Substances
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Apolipoproteins E
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Membrane Proteins
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Nerve Tissue Proteins
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TMEM106B protein, human