Abstract
5-Hydroxyindoleacetic acid (5-HIAA) and cortisol in cerebrospinal fluid (CSF), response of the dexamethasone suppression test (DST) and the clinical response to treatment with 5-hydroxytryptophan (5-HTp) plus carbidopa were studied in a group of 21 depressed inpatients (major depression with melancholia) in order to correlate biological findings with psychopathologicalones. A positive correlation was found between strong suicidal thoughts, suicidal attempts and self-aggressivity and low concentration of 5-HIAA in CSF and a less significant but still positive correlation with abnormal DST response and with clinical response to the treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / therapeutic use
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Adult
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Aggression / physiology*
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Bipolar Disorder / cerebrospinal fluid
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Bipolar Disorder / drug therapy
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Bipolar Disorder / physiopathology
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Carbidopa / therapeutic use
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Depressive Disorder / cerebrospinal fluid*
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Depressive Disorder / drug therapy
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Depressive Disorder / physiopathology
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Dexamethasone
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Female
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Humans
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Hydrocortisone / cerebrospinal fluid
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Hydroxyindoleacetic Acid / cerebrospinal fluid
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Male
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Middle Aged
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Self Mutilation / physiopathology
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Suicide, Attempted*
Substances
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Hydroxyindoleacetic Acid
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Dexamethasone
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5-Hydroxytryptophan
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Carbidopa
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Hydrocortisone