Beyond cytology: why and when does the oncologist require core tissue?

Gastrointest Endosc Clin N Am. 2014 Jan;24(1):9-17. doi: 10.1016/j.giec.2013.08.001. Epub 2013 Sep 21.

Abstract

There are 2 main reasons why oncologists may require additional tissue and a histologic section in addition to cytopathology from FNA specimens: improved diagnostic accuracy and molecular characterization of tumors. Rather than mutually exclusive diagnostic procedures, EUS-FNA and EUS-CNB must be viewed as supplementary techniques and both approaches should be incorporated as essential tools in the current endoscopic armamentarium.

Keywords: Core needle biopsy (CNB); Endoscopic ultrasound (EUS); Fine-needle aspiration (FNA); Gastrointestinal stromal tumor (GIST); Lymphoma; Pancreatic cancer.

Publication types

  • Review

MeSH terms

  • Ampulla of Vater
  • Biomarkers, Tumor / metabolism
  • Biopsy, Large-Core Needle
  • Common Bile Duct Neoplasms / diagnostic imaging
  • Common Bile Duct Neoplasms / metabolism
  • Common Bile Duct Neoplasms / pathology
  • Digestive System Neoplasms / diagnostic imaging
  • Digestive System Neoplasms / metabolism
  • Digestive System Neoplasms / pathology*
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration / adverse effects
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration / methods*
  • Gastrointestinal Stromal Tumors / diagnostic imaging
  • Gastrointestinal Stromal Tumors / metabolism
  • Gastrointestinal Stromal Tumors / pathology
  • Humans
  • Lymphoma / diagnostic imaging
  • Lymphoma / metabolism
  • Lymphoma / pathology
  • Neoplasm Staging
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology

Substances

  • Biomarkers, Tumor