Sox4you: a new player in C/EBPα leukemia

Cancer Cell. 2013 Nov 11;24(5):557-9. doi: 10.1016/j.ccr.2013.10.016.

Abstract

Although CEBPA mutations are among the most common genetic abnormalities in acute myeloid leukemia (AML), the transformation mechanism remains largely obscure. In this issue of Cancer Cell, Zhang and colleagues report that SOX4 is a direct target and crucial mediator of C/EBPα mutants in AML, revealing a potential therapeutic avenue.

Publication types

  • Comment

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / genetics*
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • SOXC Transcription Factors / genetics*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • CEBPA protein, human
  • SOX4 protein, human
  • SOXC Transcription Factors