Killing tumors by keeping ras and PI3' kinase apart

Tina L Yuan; Frank McCormick

doi:10.1016/j.ccr.2013.10.015

Killing tumors by keeping ras and PI3' kinase apart

Cancer Cell. 2013 Nov 11;24(5):562-3. doi: 10.1016/j.ccr.2013.10.015.

Authors

Tina L Yuan¹, Frank McCormick

Affiliation

¹ Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

PMID: 24229705
DOI: 10.1016/j.ccr.2013.10.015

Abstract

Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110α interaction for full activation of PI3K and tumor maintenance.

Publication types

Comment

MeSH terms

Adenocarcinoma / enzymology*
Animals
Class I Phosphatidylinositol 3-Kinases / metabolism*
Humans
Lung Neoplasms / enzymology*
Proto-Oncogene Proteins p21(ras) / genetics*

Substances

1-phosphatidylinositol 3-kinase p110 subunit, mouse
Class I Phosphatidylinositol 3-Kinases
Hras protein, mouse
Proto-Oncogene Proteins p21(ras)