Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

Georgia Fousteri; Stamatis-Nick C Liossis; Manuela Battaglia

doi:10.1016/j.clim.2013.10.006

Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity

Clin Immunol. 2013 Dec;149(3):556-65. doi: 10.1016/j.clim.2013.10.006. Epub 2013 Oct 21.

Authors

Georgia Fousteri¹, Stamatis-Nick C Liossis, Manuela Battaglia

Affiliation

¹ San Raffaele Scientific Institute, Diabetes Research Institute, Via Olgettina 58, Milan, Italy. Electronic address: fousteri.georgia@hsr.it.

PMID: 24269925
DOI: 10.1016/j.clim.2013.10.006

Abstract

PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in PTPN22 are associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type 1 diabetes. This review discusses the role of PTPN22 in T and B cells, and its function in innate immune cells, such as monocytes, dendritic cells and NK cells. We focus particularly on the complexity that underlies the function of PTPN22 in the biological processes of the immune system; such complexity has led various research groups to produce rather conflicting data.

Keywords: Autoimmunity; Autoreactive cells; Genetic predisposition; Immune tolerance; PTPN22; T regulatory cells (Treg).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity
Animals
Arthritis, Rheumatoid / enzymology
Arthritis, Rheumatoid / immunology*
Arthritis, Rheumatoid / pathology
B-Lymphocytes / enzymology
B-Lymphocytes / immunology
B-Lymphocytes / pathology
Cell Differentiation
Dendritic Cells / enzymology
Dendritic Cells / immunology
Dendritic Cells / pathology
Diabetes Mellitus, Type 1 / enzymology
Diabetes Mellitus, Type 1 / immunology*
Diabetes Mellitus, Type 1 / pathology
Humans
Immunity, Innate*
Isoenzymes / genetics
Isoenzymes / metabolism
Killer Cells, Natural / enzymology
Killer Cells, Natural / immunology
Killer Cells, Natural / pathology
Lupus Erythematosus, Systemic / enzymology
Lupus Erythematosus, Systemic / immunology*
Lupus Erythematosus, Systemic / pathology
Monocytes / enzymology
Monocytes / immunology
Monocytes / pathology
Polymorphism, Genetic
Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics*
Protein Tyrosine Phosphatase, Non-Receptor Type 22 / metabolism
T-Lymphocytes / enzymology
T-Lymphocytes / immunology
T-Lymphocytes / pathology

Substances

Isoenzymes
PTPN22 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 22