The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells

Leuk Res. 2014 Feb;38(2):225-35. doi: 10.1016/j.leukres.2013.11.007. Epub 2013 Nov 15.

Abstract

The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating cells. In vitro, meddling with the expression of GPR37 affected the CAM-DR by regulating the ability of cell adhesion and the activity of Akt and ERK in MM cells. Further studies indicated the positive role of GPR37 in the proliferation of MM cells.

Keywords: CAM-DR; GPR37; MAPK/ERK; PI3K/Akt; Proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion / drug effects
  • Cell Adhesion / genetics
  • Cell Proliferation / drug effects
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • MAP Kinase Signaling System
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / pathology
  • Proto-Oncogene Proteins c-akt / metabolism
  • RNA Interference
  • RNA, Small Interfering / pharmacology
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / physiology*
  • Tumor Cells, Cultured

Substances

  • GPR37 receptor, human
  • RNA, Small Interfering
  • Receptors, G-Protein-Coupled
  • Proto-Oncogene Proteins c-akt