Associations of cyclooxygenase 2 polymorphic genotypes with bladder cancer risk in Taiwan

Anticancer Res. 2013 Dec;33(12):5401-5.

Abstract

Aim: Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in southwestern Taiwan. However, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of cyclooxygenase 2 (Cox-2) polymorphic genotypes with Taiwan bladder cancer patients.

Materials and methods: Six polymorphic variants of Cox-2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same amount of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method.

Results: Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs20417) genotypes were positively associated with bladder cancer risk (p=0.0102). Individuals with the Cox-2 -765GC genotypes were associated with higher prostate cancer risk than those with -765GG.

Conclusion: Our findings provide evidence that the C allele of Cox-2 promoter G-765C may be associated with the overexpression of COX-2 during bladder cancer development and may be a useful marker for the early detection of bladder cancer.

Keywords: Cox-2; bladder cancer; genotype; polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Case-Control Studies
  • Cyclooxygenase 2 / genetics*
  • DNA Primers
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Promoter Regions, Genetic
  • Risk Factors
  • Taiwan
  • Urinary Bladder Neoplasms / genetics*

Substances

  • DNA Primers
  • Cyclooxygenase 2