Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature

Respir Care. 2014 Sep;59(9):e132-6. doi: 10.4187/respcare.02842. Epub 2013 Dec 10.

Abstract

We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a surgical lung biopsy and by excluding other causes of granulomatous disease. In paucisymptomatic/asymptomatic patients, as in our case, therapy is not necessary, with a good prognosis and complete recovery. NSG is a rare systemic disease similar to sarcoidosis and Wegener's granulomatosis with a benign clinical course and should always be considered for patients with nodular pulmonary lesions even with subclinical or uncommon features.

Keywords: Wegener's granulomatosis; back pain; granulomatous disease; histopathology; pulmonary nodules; sarcoidosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Back Pain / etiology
  • Granulomatosis with Polyangiitis / complications
  • Granulomatosis with Polyangiitis / diagnostic imaging*
  • Granulomatosis with Polyangiitis / pathology*
  • Humans
  • Incidental Findings
  • Lung / pathology*
  • Male
  • Middle Aged
  • Necrosis / complications
  • Necrosis / diagnostic imaging
  • Necrosis / pathology
  • Radiography
  • Remission, Spontaneous