Activated DDR1 increases RS cell survival

Blood. 2013 Dec 19;122(26):4152-4. doi: 10.1182/blood-2013-11-534123.

Abstract

In this issue of Blood, Cader et al show that tumor microenvironment promotes Epstein-Barr virus (EBV)-driven lymphomagenesis in Hodgkin lymphoma by a novel pathway involving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated by collagen(s) and contributes to the survival of Reed-Sternberg (RS) cells.

Publication types

  • Comment

MeSH terms

  • B-Lymphocytes / cytology*
  • Discoidin Domain Receptor 1
  • Epstein-Barr Virus Infections / genetics*
  • Herpesvirus 4, Human / genetics*
  • Hodgkin Disease / genetics*
  • Humans
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Viral Matrix Proteins / genetics*

Substances

  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins
  • DDR1 protein, human
  • Discoidin Domain Receptor 1
  • Receptor Protein-Tyrosine Kinases