Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

Biochim Biophys Acta. 2014 Aug;1842(8):1208-18. doi: 10.1016/j.bbadis.2013.12.011. Epub 2013 Dec 29.

Abstract

Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates.

Keywords: Misfolded proteins; Neurodegenerative diseases; Nrf2-ARE pathway; Oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antioxidant Response Elements / genetics*
  • Humans
  • NF-E2-Related Factor 2 / metabolism*
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / genetics*
  • Neurodegenerative Diseases / pathology*
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use
  • Oxidative Stress* / drug effects
  • Oxidative Stress* / genetics
  • Signal Transduction* / drug effects
  • Signal Transduction* / genetics

Substances

  • NF-E2-Related Factor 2
  • Neuroprotective Agents