Abstract
IgG heavy-chain (Gm) allotypes were determined in 11 Caucasian patients with the syndrome of demyelinating polyneuropathy associated with monoclonal IgM autoantibodies with affinity for myelin-associated glycoprotein. The frequency of Gm phenotypes in the patient group was significantly different from that seen in a normal Caucasian population.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Autoantibodies / genetics
-
Autoimmune Diseases / genetics*
-
Binding Sites, Antibody
-
Demyelinating Diseases / genetics*
-
Humans
-
Immunoglobulin G / genetics*
-
Immunoglobulin Gm Allotypes / genetics*
-
Immunoglobulin Heavy Chains / genetics*
-
Immunoglobulin M / genetics*
-
Myelin Proteins / immunology*
-
Myelin-Associated Glycoprotein
-
Phenotype
-
Polyneuropathies / genetics*
Substances
-
Autoantibodies
-
Immunoglobulin G
-
Immunoglobulin Gm Allotypes
-
Immunoglobulin Heavy Chains
-
Immunoglobulin M
-
Myelin Proteins
-
Myelin-Associated Glycoprotein