RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions

Neurosci Biobehav Rev. 2014 Oct:46 Pt 2:302-14. doi: 10.1016/j.neubiorev.2013.12.009. Epub 2014 Jan 9.

Abstract

A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.

Keywords: Brain development; G proteins; GDI1; GTPase; Intellectual disability; RAB.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / growth & development
  • Central Nervous System / metabolism
  • Cognition / physiology*
  • Cognition Disorders / genetics
  • Cognition Disorders / metabolism
  • Disease Models, Animal
  • Humans
  • Membrane Transport Modulators / metabolism*
  • Nerve Tissue Proteins / physiology*
  • Nervous System Diseases / genetics
  • Nervous System Diseases / metabolism
  • Neuroglia / metabolism
  • Neurons / metabolism
  • Protein Binding
  • rab GTP-Binding Proteins / metabolism*

Substances

  • Membrane Transport Modulators
  • Nerve Tissue Proteins
  • rab GTP-Binding Proteins