Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population

L P Lazarou; F Davies; M Sarfarazi; G A Coles; P S Harper

doi:10.1136/jmg.24.8.466

Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population

J Med Genet. 1987 Aug;24(8):466-73. doi: 10.1136/jmg.24.8.466.

Authors

L P Lazarou¹, F Davies, M Sarfarazi, G A Coles, P S Harper

Affiliation

¹ Institute of Medical Genetics, University of Wales College of Medicine, Health Park, Cardiff.

Abstract

Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alpha-Globulins / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 16*
Female
Genetic Linkage*
Humans
Lod Score*
Male
Pedigree
Polycystic Kidney Diseases / genetics*
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*
Wales

Substances

Alpha-Globulins