Abstract
Type 2 diabetes (T2D), being a complex, multi factorial metabolic disorder, its chronic complications development remains puzzled. In this case report, we describe four novel mutations in Cyt b, ATPase 8, ND1 and ND5 genes' synergistic activity as plausible factors for the secondary complications of a patient with chronic T2D.
Keywords:
Micro vascular complications; Mitochondrial mutations; Peripheral neuropathy; Type 2 diabetes.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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DNA, Mitochondrial / genetics
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / genetics*
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Electron Transport Complex I / genetics*
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Female
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Humans
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Middle Aged
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Mitochondrial Proteins / genetics*
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Mitochondrial Proton-Translocating ATPases / genetics*
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Mutation / genetics*
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NADH Dehydrogenase / genetics*
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Peripheral Nervous System Diseases / genetics*
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Peripheral Nervous System Diseases / pathology
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Prognosis
Substances
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DNA, Mitochondrial
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Mitochondrial Proteins
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MT-ND5 protein, human
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NADH Dehydrogenase
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NADH dehydrogenase subunit 1, human
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MT-ATP8 protein, human
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Mitochondrial Proton-Translocating ATPases
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Electron Transport Complex I