Abstract
We investigated the impact of gender on T2DM association with confirmed susceptibility loci. CDKN2A/2B rs10811661, KCNJ11 rs5219, and TCF7L2 rs7903146 were associated with T2DM in females, while POLI rs488846 was associated with T2DM among males; the association of SLC30A8 rs13266634 and TCF7L2 rs4506565, rs12243326, and rs12255372 with T2DM was gender-independent.
Keywords:
Genetic association studies; Single nucleotide polymorphisms; Type 2 diabetes.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Arabs / genetics
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Biomarkers / analysis
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Case-Control Studies
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Cation Transport Proteins / genetics
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Cyclin-Dependent Kinase Inhibitor p15 / genetics
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Cyclin-Dependent Kinase Inhibitor p16 / genetics
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DNA Polymerase I / genetics
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Diabetes Mellitus, Type 2 / genetics*
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Female
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Follow-Up Studies
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Genetic Association Studies
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Genetic Predisposition to Disease
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Humans
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Male
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Middle Aged
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Polymorphism, Single Nucleotide / genetics*
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Potassium Channels, Inwardly Rectifying / genetics
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Prognosis
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Proteins / genetics*
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Sex Factors
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Transcription Factor 7-Like 2 Protein / genetics
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Tunisia
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Zinc Transporter 8
Substances
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Biomarkers
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CDKN2B protein, human
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Cation Transport Proteins
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Cyclin-Dependent Kinase Inhibitor p15
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Cyclin-Dependent Kinase Inhibitor p16
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Kir6.2 channel
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Potassium Channels, Inwardly Rectifying
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Proteins
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SLC30A8 protein, human
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TCF7L2 protein, human
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Transcription Factor 7-Like 2 Protein
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Zinc Transporter 8
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DNA Polymerase I