Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs

Diabetes Res Clin Pract. 2014 Mar;103(3):e40-3. doi: 10.1016/j.diabres.2013.12.040. Epub 2014 Jan 6.

Abstract

We investigated the impact of gender on T2DM association with confirmed susceptibility loci. CDKN2A/2B rs10811661, KCNJ11 rs5219, and TCF7L2 rs7903146 were associated with T2DM in females, while POLI rs488846 was associated with T2DM among males; the association of SLC30A8 rs13266634 and TCF7L2 rs4506565, rs12243326, and rs12255372 with T2DM was gender-independent.

Keywords: Genetic association studies; Single nucleotide polymorphisms; Type 2 diabetes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabs / genetics
  • Biomarkers / analysis
  • Case-Control Studies
  • Cation Transport Proteins / genetics
  • Cyclin-Dependent Kinase Inhibitor p15 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • DNA Polymerase I / genetics
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Follow-Up Studies
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Potassium Channels, Inwardly Rectifying / genetics
  • Prognosis
  • Proteins / genetics*
  • Sex Factors
  • Transcription Factor 7-Like 2 Protein / genetics
  • Tunisia
  • Zinc Transporter 8

Substances

  • Biomarkers
  • CDKN2B protein, human
  • Cation Transport Proteins
  • Cyclin-Dependent Kinase Inhibitor p15
  • Cyclin-Dependent Kinase Inhibitor p16
  • Kir6.2 channel
  • Potassium Channels, Inwardly Rectifying
  • Proteins
  • SLC30A8 protein, human
  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein
  • Zinc Transporter 8
  • DNA Polymerase I