Abstract
CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antigens, Differentiation / genetics*
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Antigens, Differentiation / immunology
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Cell Differentiation
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Chromosome Mapping
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Chromosomes, Human, Pair 5
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DNA / genetics
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Electrophoresis, Polyacrylamide Gel
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Granulocytes / immunology
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Growth Substances / genetics*
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Humans
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Immunosorbent Techniques
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Leukemia / genetics
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Lipopolysaccharide Receptors
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Macrophages / immunology
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Mice
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Monocytes / immunology*
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Myelodysplastic Syndromes / genetics
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Nucleic Acid Hybridization
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RNA, Messenger / genetics
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Receptors, Cell Surface / genetics*
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation
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Growth Substances
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Lipopolysaccharide Receptors
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RNA, Messenger
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Receptors, Cell Surface
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DNA