Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese

Ying Zhao; Yanbo Yu; Xiaoli Tian; Xi Yang; Xueqi Li; Feng Jiang; Yundai Chen; Maowei Shi

doi:10.1371/journal.pone.0086252

Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese

PLoS One. 2014 Jan 28;9(1):e86252. doi: 10.1371/journal.pone.0086252. eCollection 2014.

Authors

Ying Zhao¹, Yanbo Yu², Xiaoli Tian³, Xi Yang³, Xueqi Li⁴, Feng Jiang⁴, Yundai Chen⁵, Maowei Shi¹

Affiliations

¹ Department of Geriatrics, Jinan Military General Hospital, Jinan, China.
² Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China.
³ Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
⁴ Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
⁵ Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

Abstract

Background: Coronary heart disease (CHD) is one of the leading causes of mortality and morbidity in China. Genetic factors that predispose individuals to CHD are unclear. In the present study, we aimed to determine whether the variation of FoxOs, a novel genetic factor associated with longevity, was associated with CHD in Han Chinese populations.

Methods: 1271 CHD patients and 1287 age-and sex-matched controls from Beijing and Harbin were included. We selected four tagging single nucleotide polymorphisms (SNPs) of FoxO1 (rs2755209, rs2721072, rs4325427 and rs17592371) and two tagging SNPs of FoxO3 (rs768023 and rs1268165). And the genotypes of these SNPs were determined in both CHD patients and non-CHD controls.

Results: For population from Beijing, four SNPs of FoxO1 and two SNPs of FoxO3 were found not to be associated with CHD (p>0.05). And this was validated in the other population from Harbin (p>0.05). After combining the two geographically isolated case-control populations, the results showed that the six SNPs did not necessarily predispose to CHD in Han Chinese(p>0.05). In stratified analysis according to gender, the history of smoking, hypertension, diabetes mellitus, hyperlipidemia and the metabolic syndrome, we further explored that neither the variants of FoxO1 nor the variants of FoxO3 might be associated with CHD (p>0.05).

Conclusion: The variants of FoxO1 and FoxO3 may not increase the prevalence of CHD in Han Chinese population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
China / epidemiology
Coronary Disease / epidemiology*
Coronary Disease / genetics*
Female
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors / genetics*
Genetic Predisposition to Disease / genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics

Substances

FOXO1 protein, human
FOXO3 protein, human
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors

Grants and funding

This study was supported by Beijing Natural Science Foundation (7092099), National Natural Science Foundation of China (81200270) and the scientific research foundation for outstanding young scientist of Shandong Province (BS2012SW012). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.