High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population

Cytokine. 2014 Mar;66(1):87-94. doi: 10.1016/j.cyto.2014.01.002. Epub 2014 Feb 1.

Abstract

Background: A case-control study was conducted to evaluate the role of IL-4 VNTR polymorphism in asthma that has been associated with various inflammatory diseases worldwide. This is the first case-control study conducted in India, investigating the role of IL-4 VNTR polymorphism in asthma pathogenesis.

Methods: A case-control study was performed with a total of 824 adult subjects, inducting 410 asthma patients and 414 healthy controls from North India. The genotypes were identified by polymerase chain reaction.

Results: Statistical analysis for the IL-4 VNTR polymorphism revealed that the Rp1 allele was significantly associated with asthma with OR=1.47, 95% CI (1.11-1.94) and p=0.005. The Rp1/Rp1 homozygous mutant genotype posed a high risk towards asthma with OR=2.39, 95% CI (0.96-6.14) and p=0.040. The Rp2/Rp1 heterozygous genotype also posed a risk towards asthma with OR=1.39, 95% CI (1.00-1.94) and p=0.040. Most of the phenotypic traits were significantly associated with the disease.

Conclusions: IL-4 VNTR polymorphism is a high risk factor for asthma in the studied North Indian population.

Keywords: Asthma; IL-4 VNTR polymorphism; North Indian population; Risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / complications
  • Asthma / genetics*
  • Case-Control Studies
  • Child, Preschool
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Humans
  • India
  • Interleukin-4 / genetics*
  • Male
  • Minisatellite Repeats / genetics*
  • Phenotype
  • Pneumonia / complications
  • Pneumonia / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors

Substances

  • IL4 protein, human
  • Interleukin-4