Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas

L Jiang; Z Zhao; D M Menke; K A Rizzo

doi:10.1038/srep03952

Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas

Sci Rep. 2014 Feb 4:4:3952. doi: 10.1038/srep03952.

Authors

L Jiang¹, Z Zhao², D M Menke¹, K A Rizzo³

Affiliations

¹ Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL.
² Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
³ 1] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN [2] Department of Pathology, Virginia Commonwealth University, Richmond, VA.

Abstract

T-cell lymphomas are aggressive lymphomas with decreased prognosis and resistance to therapy. BAG-3 and heat shock protein 70 (HSP70) function in chemotherapeutic resistance and cellular survival. Expression of BAG-3 has not been investigated in T cell lymphomas. We investigated fifty cases including benign, systemic and cutaneous T cell lymphomas. Benign T cells were negative for BAG-3 and HSP70 immunohistochemical staining. BAG-3 expression correlated with increased HSP70 expression in a subset of systemic T cell lymphoma cases co-expressing the CD30 antigen. Correlation between BAG-3, HSP70 and CD30 expression was not seen in cutaneous T cell lymphoma cases. However, these cases showed a significant increase in BAG-3 staining when compared to CD30 negative systemic T cell lymphoma cases. The differential protein expression profile of BAG-3 and HSP70 may indicate a specific role for these proteins and the ubiquitin-proteasome system/autophagy in T cell lymphomas which may help guide future targeted therapy.

MeSH terms

Adaptor Proteins, Signal Transducing / biosynthesis
Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / metabolism*
Adolescent
Adult
Aged
Aged, 80 and over
Apoptosis / drug effects
Apoptosis / genetics
Apoptosis Regulatory Proteins / biosynthesis
Apoptosis Regulatory Proteins / genetics
Apoptosis Regulatory Proteins / metabolism*
Benzoquinones / therapeutic use
Bortezomib / therapeutic use
CD3 Complex / biosynthesis
Child
Child, Preschool
Drug Resistance, Neoplasm / genetics
Female
Gene Expression
Gene Expression Profiling
HSP70 Heat-Shock Proteins / biosynthesis
HSP70 Heat-Shock Proteins / genetics
HSP70 Heat-Shock Proteins / metabolism*
HSP90 Heat-Shock Proteins / antagonists & inhibitors
Humans
Ki-1 Antigen / biosynthesis*
Lactams, Macrocyclic / therapeutic use
Lymphoma, T-Cell, Cutaneous / pathology*
Male
Middle Aged
Protein Binding
Retrospective Studies
Skin Neoplasms / pathology*
Tissue Array Analysis
Young Adult

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
BAG3 protein, human
Benzoquinones
CD3 Complex
HSP70 Heat-Shock Proteins
HSP90 Heat-Shock Proteins
Ki-1 Antigen
Lactams, Macrocyclic
tanespimycin
Bortezomib